Molecular Epidemiology Symposium: The Role of Proteomics in Disease

What can proteomics tell us about human health? This symposium will highlight some recent key advancements in the field. This includes genetic and pharmacogenomic analyses of UK Biobank (3,000 Olink proteins assessed in 50,000 volunteers), new longitudinal datasets (10,000 SomaLogic proteins assessed at four time points in 800 Lothian Birth Cohort participants), and ultra-high-throughput mass spectrometry proteomics in 20,000 volunteers from Generation Scotland. We will also get a perspective from three speakers whose work spans both academia and industry: Robert Scott (Glaxo Smith Klein), Ben Sun (Bristol Myers Squibb) and Zhana Kuncheva (BioXcelerate/Optima Partners). 

The meeting has been organised by Dr Sarah Harris and Professor Riccardo Marioni, is supported by One Health Genomics Edinburgh and sponsored by Optima Partners.

Programme

11.00 Arrival & registration

11.15    Welcome

Session 1 Chair: 

11.20   Sarah Harris (The Lothian Birth Cohorts) Proteomic biomarkers for cognitive decline prior to dementia onset

11.40    Josie Robertson (IGC) A large-scale study of the mass-spectrometry proteome in Generation Scotland: DNA methylation and beyond

12.00    Lunch

Session 2 Chair: 

13.00   Austeja Ciulkinyte (Biomedical Sciences) Brain vascular proteome changes in ageing and dementia

13.20   Lee Murphy (Edinburgh Clinical Research Facility-Genetics Core) Sequencing-based proteomics using Olink Reveal

13.40    Zhana Kuncheva (bioXcelerate) The Future of Proteomics in Causal Inference – A Parkinson’s Disease Study

14.05    Robert Scott (GSK) Q&A session: Molecular Epidemiology from an Industry Perspective 

14.30    Tea/Coffee

Session 3 Chair: 

15.00    Mine Koprulu (Queen Mary University of London) Proteogenomic insights from an international multi-cohort meta-analysis

15.30    Ben Sun (Bristol Myers Squibb) Genetic and non-genetic drivers of proteome variation in health & disease

16.00    Keenan Walker (NIA) Using Plasma Proteomics to Identify Peripheral Immune Drivers of Alzheimer’s Disease

16.30   End