Centre for Genomic & Experimental Medicine

We are part of the Institute of Genetics and Cancer at the University of Edinburgh. Our researchers undertake detailed studies of populations, families and individuals to study a wide range of health related conditions. We use state-of-the-art genetic, epigenetic, genomic, statistical, computational, biological and molecular approaches including whole genome sequencing. We apply these in model systems and in clinical studies to systematically investigate disease mechanisms. With this knowledge, we aim to improve disease prediction, prevention, diagnosis and prognosis. Our research is leading to the development of new medicines and better use of existing medicines in clinical trials.

We provide a first-class research and training environment for basic, clinical and genomics research with a strong emphasis and track record in translational research and experimental medicine. Our research has consistently obtained the highest possible ranking in national assessments of research excellence.

At the heart of CGEM strategy is the use of whole genome and epigenome methods and data, which are used to understand how genetic variation between individuals tracks with human traits and disease conditions. We utilise a powerful set of laboratory-based and computational tools to reveal both clear-cut and subtle changes in the human genome, and how this genetic variation affects the encoded information content, to develop improved understanding of a wide range of health related conditions.

As well as improving understanding of these disease states, a key activity across CGEM is translating our research findings into a clinical setting. Although each of these conditions involves a different gene or gene set, there are important methodological and technical commonalities which unifies our research.

By systematically investigating disease mechanisms through genomics, we are making important progress towards improving disease prediction, prevention and prognosis. This includes the development of new medicines and new diagnostic approaches based on genetic knowledge.