Genomics related news from across the University of Edinburgh. New research investigates the strand specificity of DNA damage and repair A new paper by a research team led by Professor Martin Taylor found that DNA damage is bypassed in the same way when copying leading and lagging strands. Two founder variants account for 90% of pathogenic BRCA alleles in Orkney and Shetland Viking Genes volunteer data has linked a harmful variant in the gene BRCA2, which increases the chance of developing breast, ovarian and prostate cancers, to a historic origin in Whalsay, Shetland. Mutation drives bacterial adaptation to immune response A team of Roslin Institute scientists have uncovered a genetic mutation that helps a common bacteria affecting humans and animals to survive against immune defences and antibiotics. Rare disease genetics reveals microtubule mechanism for ciliopathies Using patient cells, organoids and mouse models, a research team led by Professor Pleasantine Mill reveal that cilia are key to how different mutations in a single tubulin gene can result in multiple rare diseases. Genomic analysis reveals new resistance gene variation in pet pathogen Insight into the diversity of antibiotic resistance genes could aid in developing effective surveillance and interventions. IRR researchers leading national centre to tackle rare lung diseases A £9.4 million collaborative research centre will accelerate improved tests, treatments and potentially cures for thousands of people living with rare respiratory diseases Edinburgh Molecular Mechanisms Cluster (EMMC) to launch £5 million UKRI-funding has been awarded to Professor Kenneth Baillie and team to establish the EMMC, which will aim to identify the molecular mechanisms linking genetic associations and disease. Generation Scotland halfway to recruiting 20k new volunteers Generation Scotland, Scotland’s largest family health study, hit 10,000 new volunteer sign-ups at the end of February. Study uncovers the mechanism behind sickness and nausea that occur during pregnancy A new study from authors including IGC’s Professor Caroline Hayward, and using data from the Generation Scotland cohort, uncovers that sensitivity to the protein GDF15 explains why many experience sickness and nausea whilst pregnant. Butterfly and moth genomes mostly unchanged despite 250 million years of evolution Comparison of over 200 high-quality butterfly and moth genomes reveals key insights into their biology, evolution and diversification over the last 250 million years, as well as clues for conservation. Cost-effective DNA analysis could support dog research Lower-cost genomic analysis could enable affordable screening of individual dogs for genetic health conditions, and support breeding programmes. Songbird reference genome constructed to aid avian research Researchers have transcribed the genome of the white-crowned sparrow, a longstanding model wild bird species used to understand the bird biology. West Nile virus study sheds light on mitigating outbreaks Mapping development of mosquito-borne virus offers clarity on managing risk of infections. Male fertility gene discovery reveals path to success for sperm Discovery of a pair of genes that work together to protect male fertility, could provide new insights into some unexplained cases of the most severe form of infertility, research suggests. First comprehensive molecular picture of ovarian carcinosarcoma A study led by Edinburgh Cancer Centre scientists provides the first comprehensive molecular picture of ovarian carcinosarcoma (OCS), an uncommon form of ovarian cancer. Virus ancestry could help predict next pandemic A new study has identified 70 virus lineages that pose the biggest risk of causing future global pandemics. Edinburgh Next Generation of Genomics Symposium (ENGoGS23) 175 attendees were present at ENGoGS23, a symposium for early career researchers working in genomics or using genomic technologies, which was held on the 14th November 2023 at the Playfair Library. This article was published on 2024-02-02